Yongzhi Wu

Nov 22, 2023 | onlinelibrary.wiley.com | Rong Lucy He |xun zhang |Yongzhi Wu |Zhijie Weng

1 INTRODUCTION Head and neck squamous cell carcinoma (HNSCC), which develop from the mucosal epithelium in the oral cavity, pharynx, and larynx, is the sixth most common cancer worldwide (890,000 new cases and 450,000 deaths annually), contributing to the rapidly increasing burden of cancer incidence and mortality.1 HNSCC exhibit remarkable heterogeneity, and despite significant advances in diagnosis and treatment that have improved the prognosis for patients, the challenges of metastasis and...