Youhang Li

Sep 13, 2024 | biorxiv.org | Sameer Shah |Youhang Li |Shibo Li |Qing Hu

AbstractBreak-induced replication (BIR) is mutagenic, and thus its use requires tight regulation, yet the underlying mechanisms remain elusive. Here we uncover an important role of 53BP1 in suppressing BIR after end resection at double strand breaks (DSBs), distinct from its end protection activity, providing insight into the mechanisms governing BIR regulation and DSB repair pathway selection.