Youngchang Kim

Nov 16, 2023 | onlinelibrary.wiley.com | Jihan Kim |Youngchang Kim |Jaehyun Park |Ki Hyun Nam

Cyanase plays a vital role in the detoxification of cyanate and supplies a continuous nitrogen source for soil microbes by converting cyanate to ammonia and carbon dioxide in a bicarbonate-dependent reaction. The structures of cyanase complexed with dianion inhibitors, in conjunction with biochemical studies, suggest putative binding sites for substrates. However, the substrate-recognition and reaction mechanisms of cyanase remain unclear.