Youssef Arafat

2 months ago | nature.com | Oscar Maiques |Olivia Courbot |Yanbo Liu |Vittoria Graziani |Youssef Arafat |Irene Rodríguez-Hernández | +8 more

AbstractThe extracellular matrix (ECM) controls tumour dissemination. We characterise ECM organization in human and mouse tumours, identifying three regions: tumour body, proximal invasive front and distal invasive front. Invasive areas show increased matrix density, fibre thickness, length, and alignment, with unique radial fibre orientation at the distal invasive front correlating with amoeboid invasive features.