Yuanzhi Xu

Apr 10, 2024 | dovepress.com | Wei Xiang |Zhen Guo |Yiming Zhang |Yuanzhi Xu

Introduction Hypertrophic scars (HS) are a prevalent fibroproliferative skin disease that can cause pain, itching, limited joint mobility, and deformities, significantly impacting the mental well-being of patients.1 The characteristics of HS include excessive proliferation of skin fibroblasts, increased collagen generation, and deposition of extracellular matrix (ECM).2 Numerous studies have investigated the underlying causes of HS, including genetics, biomechanics, metabolism, endocrinology,...