Yuemei Li

Apr 19, 2023 | pubs.acs.org | Yuemei Li |Shuwei Zhang |Zheng Sun |Qiyuan Ma

Using CBr4 as a halogen bond donor and the source of tribromomethyl group, a halogen bond promoted tribromomethylation of N-aryltetrahydroisoquinolines was achieved. This reaction was also extended to the construction of the dibenzopyrrocoline alkaloid skeleton through a one-pot process. The mechanistic study confirmed the existence of the halogen bond.