Yulu Zhou

Jun 13, 2023 | chemistry-europe.onlinelibrary.wiley.com | Jingwen Su |Jinming Xu |Zhenyu Gu |Yulu Zhou

Abstract Difluoroalkyl groups and cyclopentenones are both important units in synthetic and medicinal chemistry. The difuoroalkylation coupled with a cyclopentenone formation still remains a challenge. Herein, we report a visible light-induced cascade difluoroalkylative 5-endo cyclization of ynones with difluoroalkyl bromides to access difluoroalkylated cyclopentenones, which may find wide applications for the concise synthesis of fluorinated cyclic molecules.