Yumin Wu

Dec 20, 2023 | chemistry-europe.onlinelibrary.wiley.com | Hui Wang |Danbo Wang |Yumin Wu |Yingjie Zhao

Hydrogen-bonded organic frameworks (HOFs) are porous crystalline materials. The pores in HOFs are usually non-covalent extrinsic pores constructed through the formation of the framework. Supramolecular macrocycles with intrinsic pores in their structures are good candidates for constructing HOFs with intrinsic pores from the macrocycles themselves, thus leading to hierarchically porous structures.

Mar 24, 2023 | onlinelibrary.wiley.com | Fengyun Shen |Zijian Xiong |Yumin Wu |Rui Peng

Graphical Abstract Framework nucleic acids (FNAs)-based peptide vaccines with different structures and sizes were constructed to understand the effect of peptide spacing and carrier rigidity on B cell activation, and reveal the significance of precise peptide organization. Epitopes from SARS-CoV-2 were assembled on the preferred FNA to construct a COVID-19 peptide vaccine prototype which effectively triggered humoral immune responses in mice.