Yung-Ching Chen

Mar 14, 2024 | nature.com | Ming-Jer Young |Shao-An Wang |Chia-Yu Liu |Kai-Cheng Hsu |Yi-Ching Wang |Yung-Ching Chen | +1 more

AbstractDrug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue is important and urgent. In this study, we found that targeting USP24 by the specific USP24 inhibitors, USP24-i and its analogues, dramatically activated autophagy in the interphase and mitotic periods of lung cancer cells by inhibiting E2F4 and TRAF6, respectively.