Yuriko Katsumata

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Articles

Smooth Muscle Cells and Fibroblasts in the Proximal Thoracic Aorta Exhibit Minor Differences Between Embryonic Origins in Angiotensin II-driven Transcriptional Alterations

Jan 24, 2025 | biorxiv.org | Sohei Ito |David Graf |Yuriko Katsumata |Jessica J Moorleghen

AbstractBackground: Thoracic aortopathy is influenced by angiotensin II (AngII) and exhibits regional heterogeneity with the proximal region of the thoracic aorta being susceptible. Smooth muscle cells (SMCs) and selected fibroblasts in this region are derived from two embryonic origins: second heart field (SHF) and cardiac neural crest (CNC).
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia - Nature Genetics

Oct 8, 2024 | nature.com | Yuriko Katsumata |Steven A. Claas |Bernardo Aguzzoli Heberle |Madeline Page |Timothy J. Hohman |Shubhabrata Mukherjee | +6 more

AbstractGenome-wide association studies (GWAS) have identified >80 Alzheimer’s disease and related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in most previous studies belie the complex nature of underlying neuropathologies.

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