Yves Briers

Jan 17, 2024 | biorxiv.org | Robby Concha-Eloko |Michiel Stock |Bernard De Baets |Yves Briers

AbstractBacteriophages (phages) are viruses that infect bacteria. Many of them produce specific enzymes called depolymerases to break down external polysaccharide structures. Accurate annotation and domain identification of these depolymerases are challenging due to their inherent sequence diversity. Hence, we present DepoScope, a machine learning tool that combines a fine-tuned ESM-2 model with a convolutional neural network to precisely identify depolymerase sequences and their enzymatic domains.