Zan Zhu

Jul 19, 2024 | biorxiv.org | Liang Bao |Zan Zhu |Ahmed Ismail |Bin Zhu

AbstractEssential gene products carry out fundamental cellular activities in interaction with other components. However, the lack of essential gene mutants and appropriate methodologies to link essential gene functions with their partners poses significant challenges. Here, we have generated deletion mutants in 32 genes previously identified as essential, with 23 mutants showing extremely slow growth in the SK36 strain of Streptococcus sanguinis.