Zemeng Wei

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Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease - Nature Communications

Apr 30, 2024 | nature.com | Chao Zhang |Ke Dong |Ming Shen Tham |Zemeng Wei |Felix Behrens |Hongyu Zhao | +2 more

AbstractMouse models of autosomal dominant polycystic kidney disease (ADPKD) show that intact primary cilia are required for cyst growth following the inactivation of polycystin-1. The signaling pathways underlying this process, termed cilia-dependent cyst activation (CDCA), remain unknown.

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