Zemeng Wei

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Anks3 mediates cilia dependent polycystin signaling and is essential for adult kidney homeostasis

2 months ago | biorxiv.org | Zemeng Wei |Michael Rehman |Jianlei Gu |Gabriel Lerner

AbstractThe existence of a cilia-dependent cyst activation (CDCA) pathway underlying autosomal dominant polycystic kidney disease was identified by showing that cyst progression following loss of polycystins is significantly suppressed by removal of structurally intact cilia.
Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease - Nature Communications

Apr 30, 2024 | nature.com | Chao Zhang |Ke Dong |Ming Shen Tham |Zemeng Wei |Felix Behrens |Hongyu Zhao | +2 more

AbstractMouse models of autosomal dominant polycystic kidney disease (ADPKD) show that intact primary cilia are required for cyst growth following the inactivation of polycystin-1. The signaling pathways underlying this process, termed cilia-dependent cyst activation (CDCA), remain unknown.

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