Zenon Toprakcioglu

Sep 13, 2023 | biorxiv.org | Zenon Toprakcioglu |Akhila Jayaram |Tuomas Knowles

AbstractThe aggregation of the amyloid-β (Aβ) peptides (Aβ42/Aβ40) into toxic amyloid fibrils and plaques is one of the molecular hallmarks in dementia and Alzheimers disease (AD). While the molecular mechanisms behind this aggregation process are not fully known, it has been shown that some biomolecules can accelerate this process while others can inhibit amyloid formation. Lipids, which are ubiquitously found in cell membranes, play a pivotal role in protein aggregation.