Zepeng Xu

3 weeks ago | biorxiv.org | Jing Li |Xuehui Ma |Zepeng Xu |Wenjing Guo

AbstractBackground: Respiratory syncytial virus (RSV) poses a significant public health threat, particularly to children and the elderly. Two protein-based vaccines and one mRNA vaccine have been approved, all targeting the prefusion conformation of the fusion (F) glycoprotein. However, it has been reported that the F protein transitions to the post-fusion state during storage, resulting in a reduction of the vaccines' immunogenicity.