Zhaohai Cui

3 weeks ago | jci.org | Jiale Chen |Lin Zhu |Zhaohai Cui |Yuxin Zhang

AbstractNewborns exhibit a heightened vulnerability to inflammatory disorders due to their underdeveloped immune system, yet the underlying mechanisms remain poorly understood. Here we report that plasma spermidine is correlated with the maturity of human newborns and reduced risk of inflammation. Administration of spermidine led to the remission of neonatal inflammation in mice.