Zheng Zhao

Sep 17, 2024 | onlinelibrary.wiley.com | Zheng Zhao |Philip E. Bourne

1 INTRODUCTION Kinases are one of the largest protein families in the human genome, comprising 538 kinase-encoding genes1 which catalyze the transfer of the γ-phosphate of ATP to phosphorylate specific substrates.2 In so doing, kinases mediate cell signal transduction which controls a variety of biological functions such as cell proliferation and apoptosis.3 Not surprisingly, mutations and dysfunction of kinases are associated with a variety of disease conditions such as cancer, inflammatory...

Aug 26, 2024 | mdpi.com | Ji Feng |Zheng Zhao |Li Ma |Huimin Gan

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Aug 11, 2024 | onlinelibrary.wiley.com | Zheng Zhao |Ye Yuan |Shuang Li |Xiaofeng Wang

1 INTRODUCTION Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by progressive memory dysfunction.1 As an important factor that threatens the health and quality of life of old individuals, the hazards of AD have caused widespread concern globally.2 About 40 million patients worldwide are currently affected by dementia, and if AD is not effectively controlled, by 2050, the number of patients with AD worldwide will be twice or more than the current level.3, 4...

Feb 25, 2024 | mdpi.com | Zheng Zhao |Yanling Zhang |Fang Yuan |Tuo Wu

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.

Mar 20, 2023 | biorxiv.org | Zheng Zhao |Philip E. Bourne

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