Zhi-De Hu

2 months ago | nature.com | Zhi-De Hu

AbstractPrevious studies have suggested that the presence of human epididymal protein 4 (HE4) in pleural fluid can be used to diagnose malignant pleural effusion (MPE) with moderate accuracy. However, the factors that affect the diagnostic accuracy of HE4 remain unknown. This study aimed to examine how age and sex influence the diagnostic accuracy of HE4.

Sep 25, 2023 | frontiersin.org | Guanghua Rong |Hongwei Cheng |Zhi Yuan Mao |Zhi-De Hu

Highlights• All systemic combinations (chemotherapy plus chemotherapy, targeted therapy plus ICI therapy, targeted therapy plus chemotherapy, and targeted plus targeted therapies) significantly improve the objective response rate in patients with aHCC. • The targeted therapy plus ICI therapy showed better therapeutic efficiency in overall survival, progression-free survival, and objective response rate, compared to the monotherapy.