Zhi-Zhang Yang

Oct 8, 2024 | nature.com | Melissa Hopper |Abigail R. Dropik |Janek S. Walker |Jordan E. Krull |Matthew J. Maurer |Zhi-Zhang Yang | +4 more

AbstractThis study sheds light on the pivotal role of the oncoprotein DEK in B-cell lymphoma. We reveal DEK expression correlates with increased tumor proliferation and inferior overall survival in cases diagnosed with low-grade B-cell lymphoma (LGBCL). We also found significant correlation between DEK expression and copy number alterations in LGBCL tumors, highlighting a novel mechanism of LGBCL pathogenesis that warrants additional exploration.