Zhonghua Liu

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Articles

Genome-wide cross-trait analysis and Mendelian randomization reveal a shared genetic etiology and causality between COVID-19 and venous thromboembolism | Communications Biology

Apr 21, 2023 | nature.com | Zilin Li |Zhonghua Liu

Study populationThe GWAS summary statistics for COVID‐19 of European ancestry were provided by the COVID-19 host genetics initiative (COVID-19 HGI) round 7 (https://www.covid19hg.org/results/, release date: 08 April 2022). COVID-19 HGI is the largest GWAS of COVID-19 to date, combining data from over 3 million individual samples across 82 large cohort studies in 35 countries.
Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study | Molecular Psychiatry

Apr 16, 2023 | nature.com | Luis Alameda |Zhonghua Liu |Celso Arango |Miguel Bernardo |Julio Bobes |Peter Jones | +14 more

AbtractStudies conducted in psychotic disorders have shown that DNA-methylation (DNAm) is sensitive to the impact of Childhood Adversity (CA). However, whether it mediates the association between CA and psychosis is yet to be explored. Epigenome wide association studies (EWAS) using the Illumina Infinium-Methylation EPIC array in peripheral blood tissue from 366 First-episode of psychosis and 517 healthy controls was performed.

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