Zhuan Zhou

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An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences - Nature Neuroscience

Jan 3, 2024 | nature.com | Yong Jiang |Jingyu Yao |Zhuan Zhou |Zuying Chai |Xinjiang Kang |Feng Wei | +2 more

AbstractThe central mechanisms underlying pain chronicity remain elusive. Here, we identify a reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the ventral tegmental area (VTA) that mediates mutual exacerbation between hyperalgesia and allodynia and their emotional consequences and, thereby, the chronicity of neuropathic pain.

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