Zhuolin Li

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Articles

Tetramerization-dependent activation of the Sir2-associated short prokaryotic Argonaute immune system - Nature Communications

Oct 3, 2024 | nature.com | Jun-Tao Zhang |Zhuolin Li |Jie Wang

AbstractEukaryotic Argonaute proteins (eAgos) utilize short nucleic acid guides to target complementary sequences for RNA silencing, while prokaryotic Agos (pAgos) provide immunity against invading plasmids or bacteriophages. The Sir2-domain associated short pAgo (SPARSA) immune system defends against invaders by depleting NAD+ and triggering cell death. However, the molecular mechanism underlying SPARSA activation remains unknown.

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