Ziming Du

Jan 1, 2024 | nature.com | Jennifer L. Guerriero |Ziming Du |Siyang Ren |Nabihah Tayob |Shaolin Mei |Sara M. Tolaney | +1 more

AbstractEmerging data suggests that HER2 intratumoral heterogeneity (ITH) is associated with therapy resistance, highlighting the need for new strategies to assess HER2 ITH. A promising approach is leveraging multiplexed tissue analysis techniques such as cyclic immunofluorescence (CyCIF), which enable visualization and quantification of 10–60 antigens at single-cell resolution from individual tissue sections.