Zinab Zaidi

Aug 26, 2024 | biorxiv.org | Akanksha Sharma |Zinab Zaidi |Devi Prasanna Dash |Soumen Kundu

AbstractProtein misfolding affects cellular fitness. This can be caused due to the toxic aggregation of one species of protein or global protein misfolding events. Since the fitness defect arises due to the multi-modal effect of misfolding, there is no consensus mechanism to alleviate this fitness defect. Here, we used adaptive laboratory evolution of thermotolerance to identify pathways contributing to proteotoxic stress resistance in S. cerevisiae.