Zinnia Ma

Oct 5, 2024 | biorxiv.org | Yuyang Zhang |Yuhang LIU |Chunfu Xu |Zinnia Ma

AbstractRecent breakthroughs in diffusion-based generative models have prompted de novo protein design, notably in generating diverse and realistic structures. Nevertheless, while existing models either excel at unconditional generation or employ residue-wise conditioning for topological control, explorations on a holistic, top-down approach to control the overall topological arrangements is still limited.