Ziyuan Guo

Dec 3, 2024 | the-scientist.com | Sneha Khedkar |Ziyuan Guo

The blood-brain barrier (BBB) regulates the passage of substances between the bloodstream and the brain, permitting essential nutrients and certain drugs to enter, while blocking harmful molecules.1 Disruptions to this critical function can lead to severe conditions like brain cancers and neurodegenerative disorders like Alzheimer’s disease.2 Despite its important physiological role in health and disease, scientist struggle to study this protective membrane, in part since the BBB of lab...

May 24, 2024 | iverifyu.com | Ziyuan Guo

For the first time, scientists have grown miniature models of the human brain that incorporate the organ’s built-in security system. The roughly sesame seed-size models include functional blood-brain barriers (BBB). In a full-size brain, the BBB would protect the delicate organ from potentially harmful substances that might be circulating through the rest of the body.

Apr 2, 2024 | sciencedirect.com | Ziyuan Guo

Introduction Although different tissues undergo distinct alterations with age, one overarching hallmark of aging is reduced stem cell function in regenerative tissues.1 The composition of the blood system evolves with age alongside well-characterized changes in hematopoietic stem cell (HSC) activity, including an age-dependent expansion of the HSC pool with decreased regenerative potential in transplantation assays, a skewed differentiation toward myeloid cell production at the expense of...

Apr 1, 2024 | sciencedirect.com | Ziyuan Guo

IntroductionEnteroendocrine cells (EECs), which originate in secretory daughters of intestinal stem cells (ISCs), constitute <1% of the epithelium.

Apr 1, 2024 | eurekalert.org | Ziyuan Guo

In a pioneering achievement, a research team led by experts at Cincinnati Children's have developed the world's first human mini-brain that incorporates a fully functional blood-brain barrier (BBB).