Digital Biomarkers

Digital biomarkers refer to measurable and objective physiological and behavioral information that is gathered through digital devices like wearables, portables, implantables, or ingestibles. This data is often utilized to understand, affect, and forecast health-related results.

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Depigmented, polymerized cat epithelium extract is safe and improves rhinitis and asthma symptoms in cat allergic patients: A real-world retrospective study.

Nov 14, 2024 | karger.com | Maria Luisa |María Desamparados |Francisco Javier

Introduction: Cat allergy is often difficult to avoid. Here, we evaluated the safety and effectiveness of a depigmented, polymerized cat epithelium extract (Dpg-pol-cat) for the treatment of allergic rhinoconjunctivitis and asthma.
Electrocardiographic strain and relationship with LV remodelling and clinical outcomes in patients with aortic stenosis undergoing transcatheter aortic valve implantation

Nov 13, 2024 | karger.com | Mohamed Ali

Introduction: Left ventricular (LV) remodelling and fibrosis is known to occur in patients with aortic stenosis (AS) and is linked to post-intervention outcomes. These myocardial changes may be detected upon the routine 12-lead electrocardiogram by the presence of a LV strain pattern (LVS-ECG).
High-Grade Sarcoma of the Pulmonary Artery That Mimicked a Pulmonary Embolism in a 39-Year-Old Patient with Recurrent Miscarriages: A Case Report

Nov 12, 2024 | karger.com | John Corbyn |Baylor Scott

Keywords: Primary pulmonary artery sarcoma, Dyspnea, Pulmonary thromboembolism, Cancer, Intrathoracic sarcomas Primary pulmonary artery sarcoma (PPAS) is a rare tumor with an estimated prevalence of 0.001–0.003% [1]. Pulmonary artery sarcomas are reported to have an average age of onset of 48 years old and can range from 13 to 86 years old [2]. Prognosis is poor with a median survival of 1.5 months without surgical intervention [3].
Mineralocorticoid receptor antagonist combined with a SGLT2 inhibitor versus SGLT2 inhibitor alone in chronic kidney disease: a meta-analysis of randomized trials

Nov 7, 2024 | karger.com | Joao Pedro |Ana Cristina |Ana Rita |João Sérgio

Background: Sodium glucose co-transporter 2 inhibitors (SGLT2i) and mineralocorticoid receptor antagonists (MRAs) reduce the progression of kidney disease. Whether the combination of these agents provides additional benefits compared to SGLT2i alone is worth exploring using data from randomized trials designed for this purpose. Aims: To assess the randomized treatment effect of MRAs combined with SGLT2i vs SGLT2i alone on markers of kidney and cardiovascular health.
Neonatal Sequential Organ Failure Assessment Score Predicts Respiratory Outcomes in Preterm Newborns with Late-Onset Sepsis: A Retrospective Study

Nov 5, 2024 | karger.com | Reggio Emilia

Introduction: Neonatal sequential organ failure assessment (nSOFA) score predicts mortality in preterm newborns. The aim of the study was to assess whether nSOFA score could predict respiratory outcomes in preterm infants with late-onset sepsis (LOS). Methods: This retrospective, observational, single-center study enrolled infants with gestational age <32 weeks born between January 2016 and June 2023 who experienced an episode of LOS during NICU stay.
Comparing two Peanut Desensitization Protocols in pre-school children: a Real-World Clinical Practice

Nov 4, 2024 | karger.com | Al Ali

This content is only available via PDF. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License .
Functional Differentiation along the Rostro-Caudal Axis of the Avian Hippocampal Formation

Nov 1, 2024 | karger.com | Santiago Gonzalez |Tom Victor

Introduction Different functional domains can be identified along the longitudinal axis of the mammalian hippocampus. We have recently hypothesized that a similar functional gradient may exist along the longitudinal axis of the avian hippocampal formation (HF) as well. If the two gradients are homologous, we would expect the caudal HF to be more responsive to acute stress than the rostral HF.
Removal of meropenem and piperacillin during experimental hemoadsorption with the HA380 cartridge

Nov 1, 2024 | karger.com | Pei Chen Connie

Introduction: Hemoadsorption can be used as adjunctive therapy for sepsis. However, there is limited evidence regarding its antibiotic removal. In this in vivo preclinical study, we aimed to evaluate the removal of meropenem and piperacillin with the HA380 hemoadsorption cartridge. Methods: Healthy adult sheep (n = 6) received 2 g of meropenem, and 4 g of piperacillin intravenously for 30 minutes followed by hemoadsorption with a HA380 cartridge at a blood flow rate of 120 mL/min for 4 hours.
Does Correction of Secondary Hyperparathyroidism with Extended-Release Calcifediol Provide Renoprotection?

Oct 24, 2024 | karger.com | de Borst

Keywords: Chronic kidney disease-mineral and bone disorder, Parathyroid hormone, Kidney function, Calcifediol Chronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by skeletal and cardiovascular abnormalities, including CKD-associated osteoporosis and vascular calcification. It is more likely to occur with more advanced CKD and has been linked with a reduced quality of life and premature mortality.
Syringotropic Lichen Planus: An Unusual Presentation of a Common Dermatosis - A Report of 2 Cases

Oct 24, 2024 | karger.com | Skin Diseases

Introduction: Lichen planus (LP) is a chronic inflammatory dermatosis that causes plaques and itchy papules on the skin, as well as erosion and ulcers in the mucous membranes. LP is characterized by a dense dermal T-cell infiltration. Perieccrine inflammation can be seen in a variety of dermatoses, but genuine lymphocyte permeation of the secretory coil or lymphocytic syringotropism is a rare sign that is typically seen in mycosis fungoides.