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1 week ago | 
erictopol.substack.com | Eric J. Topol
Audio FileAudio playback is not supported on your browser. Please upgrade. Ground Truths can also be found on Apple Podcasts, Spotify and YouTube. The UK is the world leader in human genomics, and laid the foundation for advancing medicine with the UK Biobank, Genomes England and now Our Future Health (w/ 5 million participants). Sir John Bell is a major force in driving and advising these and many other initiatives.
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2 weeks ago | 
erictopol.substack.com | Eric J. Topol
A landmark event in medicine was reported this week that has implications well beyond its likelihood of saving a baby’s life. Until now, commercially available CRISPR genome editing (Casgevy) was not capable of directly fixing a genomic defect. It was a workaround plan, that can be regarded as CRISPR 1.0. In this edition of Ground Truths, I’m going to take you through the advances in genome editing and why the new case report at NEJM heralds an extraordinary opportunity for the future of medicine.
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4 weeks ago | 
erictopol.substack.com | Eric J. Topol
Audio file, also on Apple and SpotifyAudio playback is not supported on your browser. Please upgrade. Tyler Cowen, Ph.D, is the Holbert L. Harris Professor of Economics at George Mason University. He is the author of 17 books, most recently Talent.: How to Identify Energizers, Creatives, and Winners Around the World. Tyler has been recognized as one of the most influential economists of the past decade.
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1 month ago | 
erictopol.substack.com | Eric J. Topol
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1 month ago | 
erictopol.substack.com | Eric J. Topol
In our divided world we face or avoid conflicts on a frequent basis. I turned to Bob Bordone and Joel Salinas to find out the best strategies to deal with these, including having them take on a mock conflict between each other on the merits of Covid research. Audio fileAudio playback is not supported on your browser. Please upgrade. You can also find this on Spotify and Apple podcasts with Ground Truths. The video is also posted on YouTubeTranscript with Audio LinksEric Topol (00:06):Well, hello.
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1 month ago | 
erictopol.substack.com | Eric J. Topol
While we’ve largely moved on from the French paradox myth of red wine’s protection from heart disease, there is still considerable controversy as to what level of alcohol intake is safe, potentially beneficial, or harmful. In this edition, I’m going to take you through the three recent reports, how they converge and differ, and then we’ll turn to my recent conversation with Vivek Murthy, who issued the Surgeon General report just before leaving that office in January.
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1 month ago | 
erictopol.substack.com | Eric J. Topol
Before getting right into this topic, check out recent related Ground Truths posts which are helpful for background —The Breakthrough Test for Alzheimer’s —Our Diet and Healthy Aging —The Business of Promoting Longevity and Healthspan —Our Sleep, Brain Aging, and Waste Clearance —What Can 11,000 Proteins in Our Blood Tell Us —The Emergence of Protein Organ Clocks —Exercise May Be the Single Most Potent Medical Intervention Ever Known As I wrote in Science last year, our ability to do accurate...
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1 month ago | 
erictopol.substack.com | Eric J. Topol
Back in 2020, a major milestone of progress emerged: a very accurate biomarker in the plasma —p-Tau217—for tracking brain neuropathology, without the need for cerebrospinal fluid (CSF, requiring a lumbar puncture) or a PET scan. This was from the pioneering work of Oskar Hansson and colleagues from the University of Lund in Sweden, demonstrating in multiple cohorts how this biomarker discriminated Alzheimer’s disease (AD) from other neurodegenerative diseases (non-AD).
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1 month ago | 
erictopol.substack.com | Eric J. Topol
Back in 2020, a major milestone of progress emerged: a very accurate biomarker in the plasma —p-Tau217—for tracking brain neuropathology, without the need for cerebrospinal fluid (CSF, requiring a lumbar puncture) or a PET scan. This was from the pioneering work of Oskar Hansson and colleagues from the University of Lund in Sweden, demonstrating in multiple cohorts how this biomarker discriminated Alzheimer’s disease (AD) from other neurodegenerative diseases (non-AD).
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2 months ago | 
erictopol.substack.com | Eric J. Topol
This week a new study published in Nature added to the evidence that getting a vaccine vs Shingles (Herpes Zoster) reduces the subsequent risk of dementia. It is the most rigorous study performed to date, but still leaves us with many questions.