PET

2 weeks ago | progress.org.uk | Richard Stephens

Men who carry two copies of a common genetic variant are more than twice as likely to develop dementia as those without, according to new research. The study, led by scientists in Australia, identified a strong association between dementia risk and the H63D variant in the HFE gene, a key regulator of iron metabolism. Notably, this increased risk was observed only in men, with no similar effect found in women carrying the same variant.

3 weeks ago | progress.org.uk | Joanne Delange

Ten children conceived from the same sperm donor have developed cancer, highlighting problems with regulating sperm donation internationally. In findings presented at the European Society of Human Genetics' annual conference in Milan, Italy, it was shown that this was the result of a genetic variant passed on by the sperm donor. However, the variant was not known when the donor provided sperm in 2008, and tests at the time would not have detected it.

3 weeks ago | progress.org.uk | Joanne Delange

A blood test has been developed that can rapidly diagnose thousands of rare genetic diseases in babies and children suspected of having a rare disease. Rare genetic diseases can often take years to be diagnosed, suggesting a need for faster detection methods. Researchers in Melbourne, Australia, have developed a diagnostic test that analyses thousands of proteins in blood samples to identify any protein variants that may be disease-causing.

3 weeks ago | progress.org.uk | Joanne Delange

Genome editing has been used to disrupt a type of repetitive DNA sequence that is found in certain genes and can cause severe neurological disease. The work took place at the Broad Institute, Cambridge, Massachusetts, in the lab of Professor David Liu, who first developed base editing and prime editing (see BioNews 1285).

3 weeks ago | progress.org.uk | Joanne Delange

In the evolving landscape of fertility treatment and surrogacy, commercial expos and international shows have become prominent platforms for intended parents seeking guidance, connection, and access to clinics and agencies. These events often present a glossy, welcoming image: rows of booths, friendly consultants, colourful brochures, and inspiring success stories. For many, they offer the hope of finding a clear path through what can be a confusing and emotional journey.