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2 days ago | 
sensible-med.com | Vinay Prasad |Adam Cifu |John Mandrola
The most common question we get asked is: is there a course on how to become better at critically reading medical research. Here it is!This is the second of 9 videos that we recorded as part of a course on clinical appraisal, and there will be many more to come. This and future videos will be made available as a thank you to paid subscribers.
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1 week ago | 
sensible-med.com | Adam Cifu
Every profession requires lifelong learning. Whether you are a plumber, an agent, a police officer, or a general internist, you need to keep learning throughout your career. Nobody leaves training with knowledge sufficient for a career. You need to learn to keep up and because true expertise only develops through deliberate practice. I learn from colleagues and journal articles. However, the learning I enjoy most is practice-based.
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1 week ago | 
sensible-med.com | John Mandrola
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1 week ago | 
sensible-med.com | John Mandrola
I enjoyed reading the comments on yesterday's post regarding the positive results of the ESSENCE trial of semaglutide vs placebo in patients with metabolic dysfunction-associated steatohepatitis (MASH). Thank you to those who took the time to write. I wanted to share some very brief thoughts on two basic tenets of medical practice that emerged from the thoughtful commentary. This Substack remains free of industry support due to the generosity of our readers.
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1 week ago | 
sensible-med.com | John Mandrola
Three professors, writing in the Lancet, estimated that the global prevalence of the condition is 25%. A modeling study predicted that its prevalence will rise sharply in the coming decade. The condition has a terrible name. It’s called metabolic dysfunction-associated steatohepatitis (MASH). That’s its new name. The old names, non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) were not much better.
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2 weeks ago | 
sensible-med.com | Adam Cifu
One of the many great things about being a general internist is the exposure to the wondrous diversity of humanity. I am a better person for having brief, but intense, visits with some 50 people every week. These people grew up all over the world and have worked in every imaginable field. I see people barely scraping by financially and people with unimaginable wealth. I care for 90-year-olds who look 60 and 60-year-olds who look 90.
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2 weeks ago | 
sensible-med.com | Vinay Prasad |Adam Cifu |John Mandrola
The most common question we get asked is: is there a course on how to become better at critically reading medical research. Well, now there is!This is the first of 9 videos that we recorded as part of a course on clinical appraisal, and there will be many more to come. We call our class: How Not to Get Fooled by the Medical Literature. These are topics that each of us teaches separately, but, here, for the first time, we teach them together, and the whole is more than the sum of the parts.
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2 weeks ago | 
sensible-med.com | John Mandrola
The picture below shows how a treatment can make patients better. I see four ways. The drug/procedure may work biologically. The Voltaire effect relates to his quote saying that the art of medicine consists of amusing the patient while nature cures the disease. AKA: natural history. Placebo effects can also contribute. I will show you an elegant experiment demonstrating how positive energy and words can add to improvement. Indeed the encounter is an opportunity to heal.
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3 weeks ago | 
sensible-med.com | Adam Cifu
Because some readers commented that Vinay’s post last Saturday was more politics than Sensible Medicine, I hesitate to even post this one. Although I won’t comment on the content of Vinay’s post, I do think his belonged here. The current politics have daily effects on us in medicine, especially those of us in academic medicine.
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3 weeks ago | 
sensible-med.com | Adam Cifu
“From all my years in the classroom, the lessons that stayed with me most vividly have been the digressions, asides, anecdotes told mostly to relieve the lecturer’s own boredom.” Kathleen RooneyIn my lifetime of listening to lectures, most have been forgettable, leaving me bemoaning an hour of life wasted. Thankfully, in recent years, at least I can be productive — or distracted — thanks to my phone during the most painful lecture.