Separation Science

Separation Science is the top online hub for information on methods, applications, troubleshooting, and training related to chromatography and mass spectrometry.

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Pittcon 2025: Analytical Innovations from Industry Leaders

Mar 10, 2025 | sepscience.com | Aimee Cichocki |Benjamin Lilienfeld

The Pittcon 2025 Conference and Expo took place in Boston, Massachusetts, March 1–5, 2025. This event united a global community of scientists to uncover emerging breakthroughs in analytical chemistry and applied spectroscopy. Attendees immersed themselves in specialized courses, interactive workshops, and lively discussions focused on advancing techniques in chromatography, mass spectrometry, data analysis, and more.
Clinical Mass Spectrometry: From Specialist Labs to Routine Settings

Mar 10, 2025 | sepscience.com | Aimee Cichocki |Benjamin Lilienfeld

Mass spectrometry, long considered the benchmark technique for precise and specific clinical testing, typically requires specialized expertise and manual, time-intensive workflows. Complex instrument setups and varied protocols can limit the use of clinical mass spectrometry techniques to specialized facilities, rendering the technique impractical for round-the-clock clinical needs.
Elescan XRF-100: Isotope-Free Analyzer Revolutionizes Mineral Processing

Mar 9, 2025 | sepscience.com | Aimee Cichocki |Susanne Soelter |Stephan Buckenmaier

Thermo Fisher Scientific has launched the Elescan XRF-100, an online multi-stream elemental slurry analyzer that accelerates decision-making in mineral processing. By delivering real-time data for multiple slurry streams, this system helps operators respond swiftly to changing conditions, reduce material losses, and stabilize product quality. Below is a closer look at its key features, benefits, and applications.
Proteomics: Key Techniques, Emerging Trends, and Applications

Feb 13, 2025 | sepscience.com | Adam Dickie |Aimee Cichocki |Damon Anderson

Proteomics explores the world of proteins—nature’s builders, movers, and messengers. By mapping the full range of proteins in cells or tissues, scientists pinpoint how they affect growth, function, and disease. In this article, we’ll examine core techniques and emerging trends that highlight why proteomics is vital to modern biology. What is proteomics? At its core, proteomics analyzes the entire set of proteins—called the proteome—in a cell, tissue, or organism.
Green Chromatography: Reducing Environmental Impact in Lab Practices

Dec 13, 2024 | sepscience.com | Aimee Cichocki

As environmental concerns become more pressing, laboratories across the globe are adopting greener practices to reduce their ecological footprint. Chromatographic methods are evolving with this trend, and we are seeing significant advancements in terms of sustainability. By focusing on reducing solvent use, minimizing energy consumption, and optimizing waste management, green chromatography is transforming lab operations while maintaining efficiency and accuracy.
How Analytical Techniques are Helping Solve a Newfoundland Mystery

Dec 11, 2024 | sepscience.com | Aimee Cichocki

In September 2024, white blobs, ranging in size up to around 15 centimeters in diameter, began washing ashore along Newfoundland’s beaches, prompting curiosity among locals and the broader community. To solve this mystery, Dr. Chris Kozak, a chemistry professor at Memorial University, Newfoundland, applied a suite of analytical techniques to study the chemical composition of the material in an attempt to identify its origin.
Tackling Scope 3 Emissions: The Role of Analytical Scientists in Greening Labs

Dec 11, 2024 | sepscience.com | Aimee Cichocki

As the biotech and pharmaceutical industries strive to align with global climate goals, addressing Scope 3 emissions has become a critical priority. According to the recently released My Green Lab (MGL) 2024 Carbon Impact of Biotech & Pharma Report, Scope 3 emissions—indirect emissions resulting primarily from the supply chain—make up the largest share of the industry’s carbon footprint.
Relative Response Factor: Accurate Quantification in Chromatography

Oct 3, 2024 | sepscience.com | Aimee Cichocki

Accurate quantification in chromatography is essential for reliable results. A critical tool in this process is the relative response factor (RRF), a calculated value that enables scientists to account for varying detector responses to different compounds. This article explores the importance of RRF, how it's calculated, and its role in ensuring precision in chromatography. In chromatography, the relative response factor (RRF) compares the detector’s response between two compounds.
From Lab to Field: The Impact of Portable FTIR in Forensics

Sep 9, 2024 | sepscience.com | Aimee Cichocki |Chris Brown

In the high-stakes world of forensic science, speed and accuracy are paramount. For firefighters, hazmat teams, police groups, and government agencies, every second counts when identifying substances, analyzing evidence, and making critical decisions that impact public safety. The adoption of advanced Fourier-transform infrared (FTIR) spectroscopy is revolutionizing the field, offering rapid, on-site analysis capabilities that were previously confined to the laboratory. Dr. Christopher D.
Sample Prep Workflows for Low-Level LC-MS/MS Analysis

Sep 5, 2024 | sepscience.com | Aimee Cichocki |Stephanie Marin

In the pursuit of accurate and sensitive LC-MS/MS analysis, particularly at low analyte concentrations, sample preparation is a crucial step that can make or break the success of an assay. Separation Science recently engaged in an insightful discussion with Dr. Stephanie Marin, the Global Clinical Market Development Manager at Phenomenex, to explore the intricacies of sample preparation workflows for low-level LC-MS/MS analysis.