Aaron Smith

Nov 20, 2024 | mdpi.com | Catherine Lyons |Ruyun Jin |Aaron Smith |Hong Zhu

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Oct 24, 2024 | preprints.org | Catherine Lyons |Ruyun Jin |Aaron Smith |Hong Zhu

Preprint Communication Version 1 This version is not peer-reviewed Version 1 : Received: 23 October 2024 / Approved: 23 October 2024 / Online: 24 October 2024 (10:10:46 CEST) Lyons, C. E.; Jin, R.; Smith, A. D.; Zhu, H.; Slingluff, Jr, C. L. Adverse Events as a Function of Biologic Sex in a Multicenter Clinical Trial of Melanoma Vaccines. Preprints 2024, 2024101881. https://doi.org/10.20944/preprints202410.1881.v1 Lyons, C. E.; Jin, R.; Smith, A. D.; Zhu, H.; Slingluff, Jr, C. L.

May 12, 2024 | nature.com | Thomas G. Hayhow |Rodrigo J. Carbajo |David Fisher |Frederick W. Goldberg |Lorna Hopcroft |Philip Hopcroft | +5 more

AbstractTargeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROTAC) degrader of ERα. In vitro studies with this PROTAC demonstrate excellent ERα degradation and ER antagonism in ER+ breast cancer cell lines. However, upon dosing the compound in vivo we observe an in vitro-in vivo disconnect.

Jan 15, 2024 | newideal.aynrand.org | Aaron Smith

In August 1963, the spiritual leader of the American civil rights movement, Martin Luther King Jr., delivered a now-famous speech from the steps of the Lincoln Memorial in Washington, D.C., calling for an end to racism in America.

Nov 22, 2023 | newideal.aynrand.org | Aaron Smith

Stoicism is trending today in the form of “life-hacks” for self-improvement. “Become invincible.” “Master your emotions.” “Turn obstacles into opportunities.” But in a series of articles highlighting themes from her book Stoic Wisdom: Ancient Lessons for Modern Resilience, Dr. Nancy Sherman — a Georgetown University philosophy professor specializing in ancient Greek and Roman ethics — argues that this popular “self-help” Stoicism misses the philosophy’s actual message.