Aaron Straight

Sep 5, 2024 | nature.com | Nicolas Altemose |Aaron Straight

AbstractWe recently developed directed methylation with long-read sequencing (DiMeLo-seq) to map protein–DNA interactions genome wide. DiMeLo-seq is capable of mapping multiple interaction sites on single DNA molecules, profiling protein binding in the context of endogenous DNA methylation, identifying haplotype-specific protein–DNA interactions and mapping protein–DNA interactions in repetitive regions of the genome that are difficult to study with short-read methods.

Jan 16, 2024 | nature.com | Jessen V Bredeson |Owen Smith |Jessica Lyons |Jane Grimwood |Jeremy Schmutz |Mustafa K. Khokha | +13 more

AbstractFrogs are an ecologically diverse and phylogenetically ancient group of anuran amphibians that include important vertebrate cell and developmental model systems, notably the genus Xenopus. Here we report a high-quality reference genome sequence for the western clawed frog, Xenopus tropicalis, along with draft chromosome-scale sequences of three distantly related emerging model frog species, Eleutherodactylus coqui, Engystomops pustulosus, and Hymenochirus boettgeri.