Abhijit Sarkar

Dec 19, 2024 | mdpi.com | Abhijit Sarkar

1. IntroductionClean air is essential for sustaining life, yet the escalating issue of air pollution has become a global concern. Rapid urbanization, industrialization, population growth, and unchecked human activities have all contributed to the growing pressure on air quality [,]. Like other continents, Europe also grapples with air pollution, particularly in industry-rich urban areas and high-traffic zones.

Sep 9, 2024 | digitalcommons.library.tmc.edu | Yue Hu |Abhijit Sarkar |Kevin Song |Sara Michael

AbstractChimeric antigen receptor (CAR) T cell therapy is hindered in solid tumor treatment due to the immunosuppressive tumor microenvironment and suboptimal T cell persistence. Current strategies do not address nutrient competition in the microenvironment. Hence, we present a metabolic refueling approach using inosine as an alternative fuel. CAR T cells were engineered to express membrane-bound CD26 and cytoplasmic adenosine deaminase 1 (ADA1), converting adenosine to inosine.

Apr 29, 2024 | cell.com | Yue Hu |Inflammatory Diseases |Abhijit Sarkar |Kevin Song

Highlights•ADA1 is conditionally secreted in response to CD3/CD26 stimulation•Co-overexpression of ADA1 and CD26 is essential for T cell trafficking and expansion•Ecto-ADA1 boosts CAR T cell expansion without impacting tumor cells•MR-CAR is a strategy to improve CAR T cell therapy for solid tumorsSummaryChimeric antigen receptor (CAR) T cell therapy is hindered in solid tumor treatment due to the immunosuppressive tumor microenvironment and suboptimal T cell persistence.

Feb 5, 2024 | medium.com | Abhijit Sarkar

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Feb 4, 2024 | medium.com | Abhijit Sarkar

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