
Sara Michael
Vice President and General Manager, Verywell Health at Dotdash
SVP & Group General Manager, Health @dotdashmeredith @verywell @health_com_
Articles
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Sep 9, 2024 |
digitalcommons.library.tmc.edu | Yue Hu |Abhijit Sarkar |Kevin Song |Sara Michael
AbstractChimeric antigen receptor (CAR) T cell therapy is hindered in solid tumor treatment due to the immunosuppressive tumor microenvironment and suboptimal T cell persistence. Current strategies do not address nutrient competition in the microenvironment. Hence, we present a metabolic refueling approach using inosine as an alternative fuel. CAR T cells were engineered to express membrane-bound CD26 and cytoplasmic adenosine deaminase 1 (ADA1), converting adenosine to inosine.
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Sep 22, 2023 |
biorxiv.org | Yue Hu |Abhijit Sarkar |Kevin Song |Sara Michael
AbstractCAR T cell therapy has revolutionized the treatment of hematologic malignancies, but its efficacy in solid tumors remains limited due to the immunosuppressive nature of the tumor microenvironment and the inability of T cells to persist and traffic to the tumor site.
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RT @bessbell: Whether or not you watch Busy Tonight, it's important to know when you give women shows we get to mainstream our voices and e…

Connie Schultz nails it again. And I couldn’t possibly love Michelle Obama more (and Sheryl Sandburg, but yep that Lean In business comes at a cost.) These women, though. 🙌 https://t.co/U01GOaWREH

RT @GlennKesslerWP: "looking at" is Trumpspeak for something he just conjured up at that moment. Congress isn't even in town. No bill has b…