Abigail F. Groff

Feb 8, 2023 | cell.com | Alexander K. Godfrey |Helen Skaletsky |Daniel W Bellott |Abigail F. Groff

Highlights•Analyzed gene expression in sex chromosome aneuploidy samples using linear models•Xi and Xa transcriptomes are modular•38% of X chromosome genes are affected by Xi copy number—in cis and in trans•10 X chromosome genes likely contribute to male-female differences in somatic tissuesSummaryThe “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa).