Daniel W Bellott

Jan 3, 2025 | genome.cshlp.org | Shruthi Rengarajan |Jason Derks |Daniel W Bellott |Nikolai Slavov

1,2,4 1Whitehead Institute, Cambridge, Massachusetts 02142, USA; 2Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; 3Departments of Bioengineering, Biology, Chemistry, and Chemical Biology, Single Cell Proteomics Center, and Barnett Institute, Northeastern University, Boston, Massachusetts 02115, USA; 4Howard Hughes Medical Institute, Whitehead Institute, Cambridge, Massachusetts 02142, USA Corresponding author: dcpage{at}wi.mit.edu Footnotes...

Jun 11, 2024 | biorxiv.org | Daniel W Bellott |Jennifer Hughes |Helen Skaletsky |Erik Owen

AbstractA recent publication describing the assembly of the Y chromosomes of 43 males was remarkable not only for its ambitious technical scope, but also for the startling suggestion that the boundary of the pseudoautosomal region 1 (PAR1), where the human X and Y chromosomes engage in crossing-over during male meiosis, lies 500 kb distal to its previously reported location. Where is the boundary of the human PAR1?

Feb 8, 2023 | cell.com | Alexander K. Godfrey |Helen Skaletsky |Daniel W Bellott |Abigail F. Groff

Highlights•Analyzed gene expression in sex chromosome aneuploidy samples using linear models•Xi and Xa transcriptomes are modular•38% of X chromosome genes are affected by Xi copy number—in cis and in trans•10 X chromosome genes likely contribute to male-female differences in somatic tissuesSummaryThe “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa).