Academia Sinica

Jan 14, 2025 | pubs.rsc.org | Febri Baskoro |Academia Sinica |Aerospace Engineering |Institut Teknologi Bandung

Recent advances in p-type polymeric electrode materials towards high-voltage 4.0 V-class organic lithium-ion batteries Lithium-ion batteries stand at the forefront of energy storage technologies, facilitating the transition towards sustainable and electrified systems. However, to meet the increasing demands for energy density, safety, and longevity, the development of high-performance electrode materials is paramount.

Jan 13, 2025 | jbc.org | Gary Chen |Academia Sinica

Key WordsTaustabilityfibrillizationseedingtauopathyIntroductionTauopathies cover a range of neurodegenerative diseases characterized by the presence of neuronal tau inclusions, including Alzheimer’s disease (AD), Pick’s disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal dementia and Parkinsonism linked to chromosome 17 (1). Under physiological conditions, tau functions as a microtubule-binding protein that stabilizes microtubules.

Oct 14, 2024 | academic.oup.com | Carnegie Mellon |Academia Sinica

In causal inference, we often seek to make inferences about the population effect of a binary treatment on an outcome variable by contrasting means of potential outcomes and (ie, counterfactuals), where represents the (bounded) outcome of a random individual under treatment t, (Neyman, 1923; Rubin, 1974). Identification of this contrast, called the average causal effect (ACE), from observational data (ie, non-experimental studies) requires untestable assumptions.

Sep 16, 2024 | icob.sinica.edu.tw | Academia Sinica

Development of animal body plans is controlled by large networks of regulatory genes. Gene regulatory networks (GRNs) describe signaling pathways leading to the activation of DNA-recognizing regulatory proteins (transcription factors) and the interactions between the transcription factors and the modular DNA sequence elements that control spatial and temporal expression of regulatory genes.

Sep 14, 2024 | academic.oup.com | Roosevelt Rd |Academia Sinica

Meiotic recombination generates genetic diversity and promotes proper chromosomal segregation of parental chromosomes. Homology search and strand exchange between homologous DNAs, critical for crossing over in meiosis (1), require a set of recombinases polymerized on single-stranded DNAs (ssDNAs) called the nucleoprotein filament. For most eukaryotes, meiosis-specific Dmc1 plays a pivotal role in meiotic recombination (2).