Adam M. Dinan

Oct 11, 2024 | nature.com | Charlotte Lefèvre |Georgia Cook |Adam M. Dinan |Hazel Stewart |Alex Nicholson |Valeria Lulla | +7 more

AbstractZika virus (ZIKV), an emerging mosquito-borne flavivirus, is associated with congenital neurological complications. Here, we investigate potential pathological correlates of virus gene expression in representative ZIKV strains through RNA sequencing and ribosome profiling. In addition to the single long polyprotein found in all flaviviruses, we identify the translation of unrecognised upstream open reading frames (uORFs) in the genomic 5′ region.

Jul 4, 2024 | science.org | Akiko Oguchi |Aaron Weimann |Bojana Müller-Durovic |Adam M. Dinan

Editor’s summaryIndividuals with cystic fibrosis and other chronic inflammatory lung diseases are particularly vulnerable to colonization by Pseudomonas aeruginosa. Epidemic clones have emerged in certain patient groups that are associated with poor clinical outcomes and antimicrobial resistance. Weimann et al. investigated when and how such clones emerge by accessing international collections of clinical and environmental strains of P. aeruginosa amassed over the past century.