Hazel Stewart

Oct 11, 2024 | nature.com | Charlotte Lefèvre |Georgia Cook |Adam M. Dinan |Hazel Stewart |Alex Nicholson |Valeria Lulla | +7 more

AbstractZika virus (ZIKV), an emerging mosquito-borne flavivirus, is associated with congenital neurological complications. Here, we investigate potential pathological correlates of virus gene expression in representative ZIKV strains through RNA sequencing and ribosome profiling. In addition to the single long polyprotein found in all flaviviruses, we identify the translation of unrecognised upstream open reading frames (uORFs) in the genomic 5′ region.