Adrian Lee

Jan 23, 2025 | nature.com | Fresia Pareja |Rohit Bhargava |Virginia F. Borges |Edi Brogi |Fatima Cardoso |Christine Desmedt | +16 more

AbstractSpecial histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges.

Nov 8, 2024 | nature.com | Fangyuan Chen |George Tseng |Julia Foldi |Adrian Lee

AbstractUnderstanding interplay of breast cancer and microenvironment is critical. Here we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER + /HER2- ILCs. We found proliferative subtype associated with increased suppressive immune infiltration, and defined a signature associated with lower proliferative, pro-inflammatory TAM infiltration, and improved survival in ER+ breast cancer.

Jul 19, 2024 | nature.com | Steffi Oesterreich |Adrian Lee |Fangyuan Chen |Rachel C. Jankowitz |Rita A. Mukhtar |Matthew J Sikora | +3 more

AbstractThere is growing awareness of the unique etiology, biology, and clinical presentation of invasive lobular breast cancer (ILC), but additional research is needed to ensure translation of findings into management and treatment guidelines. We conducted a survey with input from breast cancer physicians, laboratory-based researchers, and patients to analyze the current understanding of ILC, and identify consensus research questions.

May 29, 2024 | jdsupra.com | Brendan Coffman |Jamillia Ferris |Adrian Lee

DOJ's Most Recent Monopolization Case Reflects Several Agency Priorities Including Expansion of Section 2 to Respond to Headline-Grabbing Popular DemandsOn May 23, 2024, the U.S. Department of Justice (DOJ), along with 30 state and district attorneys general, filed a lawsuit seeking to break-up Live Nation Entertainment Inc.

Mar 8, 2024 | jdsupra.com | Brendan Coffman |Adrian Lee |Aayush Patel

On March 5, 2024, the Department of Justice’s (DOJ’s) Antitrust Division, the Federal Trade Commission (FTC), and the Department of Health and Human Services (HHS) jointly issued a Request for Information (RFI) to solicit public comments about the impacts of consolidation in the healthcare industry.1The agencies’ inquiry reflects the Biden Administration’s continued scrutiny of competition and prices in the healthcare and pharmaceutical industries and its broader initiative to apply antitrust...