Agin Ravindran

Nov 24, 2024 | biorxiv.org | Gabriela Rodriguez |Gabriela Rodríguez |Agin Ravindran |Srivastava Akanksha |Favour Oyelami

AbstractGene expression programs underpin the development of shared phenotypes, yet the importance of transcript complexity in shaping mammalian evolution remains unclear. Here we present a comprehensive long-read direct RNA sequencing atlas of full-length transcripts and their m6A modifications across six tissues (hippocampus, frontal cortex, cerebellum, testes, skeletal muscle, and liver) in five mammals (human, mouse, rat, dog, and cow) and a non-mammalian out-group (chicken).

Mar 2, 2024 | biorxiv.org | Pablo Mateos |Aditya Sethi |Agin Ravindran |Akanksha Srivastava

AbstractThe epitranscriptome embodies many new and largely unexplored functions of RNA. A significant roadblock hindering progress in epitranscriptomics is the identification of more than one modification in individual transcript molecules. We address this with CHEUI (CH3 (methylation) Estimation Using Ionic current).

Jan 14, 2024 | biorxiv.org | Pablo Mateos |Aditya Sethi |Agin Ravindran |Akanksha Srivastava

AbstractThe epitranscriptome embodies many new and largely unexplored functions of RNA. A major roadblock in the epitranscriptomics field is the lack of transcriptome-wide methods to detect more than a single RNA modification type at a time, identify RNA modifications in individual molecules, and estimate modification stoichiometry accurately.

Jan 3, 2024 | biorxiv.org | Pablo Mateos |Aditya Sethi |Agin Ravindran |Akanksha Srivastava

AbstractThe epitranscriptome embodies many new and largely unexplored functions of RNA. A major roadblock in the epitranscriptomics field is the lack of transcriptome-wide methods to detect more than a single RNA modification type at a time, identify RNA modifications in individual molecules, and estimate modification stoichiometry accurately.