Agnes Karasik

2 weeks ago | biorxiv.org | Agnes Karasik |Grant Jones |Nicholas Guydosh |Kidney Diseases

AbstractRNase L is an endonuclease that responds to infections by cleaving most host- and pathogen-derived single-stranded RNAs. This widespread RNA cleavage can lead to death of the infected cell via the ribotoxic stress response (RSR). An ongoing challenge is to understand how RNase L's endonuclease activity triggers cell death to benefit the host.