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Nov 23, 2024 | 
link.springer.com | Kidney Diseases
AbstractMood disorders, particularly depression and anxiety, are associated with zinc dyshomeostasis and aberrant GABAergic signaling. Activation of ZnR/GPR39 by synaptic zinc in the hippocampus triggers phosphorylation of extracellular regulated kinase (ERK1/2), which regulates the K+/Cl− cotransporter (KCC2) and thereby GABAergic inhibitory neurotransmission and seizure activity.
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Nov 8, 2024 | 
trialsjournal.biomedcentral.com | Juan Carlos |Johns Hopkins |Kidney Diseases
The objectives of the ANDES trial are to evaluate the implementation and effectiveness of a CHW-led multicomponent strategy to reduce hypertension and type 2 diabetes in an underserved Andean population in Puno, Peru. The ANDES strategy adapts several components of the WHO HEARTS technical package and is designed to lower blood pressure by targeting improvements in antihypertensive medication adherence and healthy lifestyle behaviors.
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Nov 3, 2024 | 
academic.oup.com | Kidney Diseases |Johns Hopkins
OVO is required for female germ cell viability but has no known function in the male germline in Drosophila. ovo is autoregulated by two antagonistic isoforms, OVO-A and OVO-B. All ovo– alleles were created as partial revertants of the antimorphic ovoD1 allele. Creation of new targeted alleles in an ovo+ background indicated that disrupting the germline-specific exon extension of ovo-B leads to an arrested egg chamber phenotype, rather than germ cell death.
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Oct 30, 2024 | 
scitechdaily.com | Kidney Diseases
Teens undergoing weight-loss surgery showed enduring benefits over 10 years, with major reductions in BMI and obesity-related diseases like diabetes and hypertension, outperforming results seen in adults. A decade-long study reveals that adolescents who received weight-loss surgery significantly maintained reduced BMI and improved major health markers, such as diabetes and hypertension, 10 years post-surgery.
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Oct 30, 2024 | 
academic.oup.com | Liver Diseases |Virginia Commonwealth |Kidney Diseases
Withdrawal of nucleos(t)ide analog (NA) therapy is associated with hepatitis B surface antigen (HBsAg) loss and sustained, off-therapy partial cure (normal ALT [≤30 U/L males, ≤20 U/L females) with HBV DNA <2000 IU/mL) but should be offered only to those most likely to benefit. HBVRNA may be useful for risk stratification.
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Oct 17, 2024 | 
cardiab.biomedcentral.com | Kidney Diseases
The study was conducted at the National Institutes of Health Clinical Center (NIHCC) under protocol 04-DK-0021 (clinical trial number: NCT00071526) and approved by the Institutional Review Boards of NIDDK, NIH. Participants were recruited from the Washington DC area community from November 2013 to 2017, using recruitment flyers and advertisements displayed across NIHCC, community, social media, and online registries.
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Sep 19, 2024 | 01128-8&sz=64)
cell.com | Kidney Diseases |Miguel Almeida |Axel Poulet |Bioinformatics Group
Keywords PIWI piRNA spermatogenesis readthrough transcription stress evolution fertility transposon mobile genetic element germ cell Research topic(s) CP: Molecular biology Introduction PIWI-interacting RNAs (piRNAs) and their PIWI protein partners are essential for germ cell health and the survival of species.1,2,3,4,5 piRNA pathways establish restriction of mobile genetic elements to protect genome integrity.6,7 Mutations in essential piRNA pathway genes result in sterility in animals and...
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Aug 27, 2024 | 
diabetesjournals.org | Kidney Diseases
Over a hundred years ago, the discovery of insulin—one of the most notable scientific advances of the 20th century—ushered in a new era in chronic disease management. Specifically, with the clinical availability of insulin, an incredible paradigm shift emerged that changed type 1 diabetes from a rapidly progressive disease associated with significant morbidity and mortality to a more manageable chronic condition.
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Aug 19, 2024 | 
communities.springernature.com | Thamarasee Jeewandara |Biomedical Engineering |Kidney Diseases
Like Liked by India Ambler Choose a social network to share with, or copy the shortened URL to share elsewhere Share with... ...or copy the link This is a representation of how your post may appear on social media.
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Aug 19, 2024 | 
bmccancer.biomedcentral.com | Kidney Diseases
Our study provides evidence-based support for clinical practice, including the following findings: 1) Almost all second-line treatments provided survival advantages over the placebo group in terms of OS, PFS, ORR, TTP, and DCR. 2) None of the second-line treatments showed safety or toxicity advantages over the placebo group.
