Agnieszka M. Szemiel

Sep 13, 2024 | biorxiv.org | Agnieszka M. Szemiel |Lucy Macdonald |Karen Kerr |Theodoros Simakou

AbstractFactors governing the coagulopathy and pneumonitis associated with severe viral infections remain unresolved. We previously found that the expression of protein S (PROS1) is increased in lung epithelium of patients with mild COVID-19 as compared to severe COVID-19. We hypothesised that PROS1 may exert a local effect that protects the upper airway against severe inflammation by modulating epithelial and myeloid cell responses.