Lucy Macdonald

Nov 27, 2024 | cell.com | Lucy Macdonald |Aziza Elmesmari |Domenico Somma |Jack Frew |Clara Di Mario |Roopa Madhu | +30 more

Keywordsimmune tolerancearthritisdisease remissiondendritic cellssynovial tissuespatial transcriptomicsT cellsIntroductionRheumatoid arthritis (RA) is an inflammatory joint disease with systemic comorbidities, driven by the breach of immune tolerance.1 Advances in targeted therapies2 have transformed the management of RA.

Sep 13, 2024 | biorxiv.org | Agnieszka M. Szemiel |Lucy Macdonald |Karen Kerr |Theodoros Simakou

AbstractFactors governing the coagulopathy and pneumonitis associated with severe viral infections remain unresolved. We previously found that the expression of protein S (PROS1) is increased in lung epithelium of patients with mild COVID-19 as compared to severe COVID-19. We hypothesised that PROS1 may exert a local effect that protects the upper airway against severe inflammation by modulating epithelial and myeloid cell responses.

Jul 19, 2024 | biorxiv.org | Lucy Macdonald |Aziza Elmesmari |Domenico Somma |Jack Frew

AbstractCurrent rheumatoid arthritis (RA) treatments do not restore immune tolerance. Investigating dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to re-instate tolerance in RA. With single-cell and spatial-transcriptomics of synovial tissue biopsies, validated by micro co-culture systems, we identified condition and niche-specific myeloid DC clusters with distinct differentiation trajectories and functions.

Feb 7, 2024 | telegraph.co.uk | Lucy Macdonald |Lucy Aspden-Kean

Wearing a helmet is now seen as essential on the slopes Credit: David Andre The adrenaline rush of skiing and snowboarding means inevitably there are inherent risks. In recent years, resort bosses have cited a rise in accidents on the pistes.

Nov 24, 2023 | en.mogaznews.com | Lucy Macdonald |James Dunlevie

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