Aida S Hansen

Mar 28, 2024 | nature.com | Bao-cun Zhang |Ryo Narita |Aida S Hansen |Jinrong Huang |Emil K Nilsson |Christina Zeiler | +6 more

AbstractThe cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex assembly and induction of interferon and inflammatory cytokines. Here we report that cGAMP stimulation leads to a transient decline in ER cholesterol levels, mediated by Sterol O-Acyltransferase 1-dependent cholesterol esterification.