Jinrong Huang

Mar 28, 2024 | nature.com | Bao-cun Zhang |Ryo Narita |Aida S Hansen |Jinrong Huang |Emil K Nilsson |Christina Zeiler | +6 more

AbstractThe cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex assembly and induction of interferon and inflammatory cytokines. Here we report that cGAMP stimulation leads to a transient decline in ER cholesterol levels, mediated by Sterol O-Acyltransferase 1-dependent cholesterol esterification.

Jul 9, 2023 | mdpi.com | Hua Yang |Jialin Zhang |Zhuoran Li |Jinrong Huang

Abstract:The effect of ZnO nanoparticles (ZnO NPs), with different concentrations in simulated water, on the activity of sulfate-reducing bacteria (SRB) and their adhesion behaviour on stainless-steel surfaces, with and without visible light treatment, were investigated.

Feb 17, 2023 | cell.com | Bin Liu |Ran Chen |Yidan Zhang |Jinrong Huang

IntroductionCancer cells are continuously exposed to various stresses due to the persistent activity of oncogenic pathways and hazardous cancer environments. Consequently, they become addicted to survival-promoting stress response pathways and to elevated activity of homeostasis-preserving cellular processes, whose targeting is opening new possibilities for cancer therapy. 1Luo J. Solimini N.L. Elledge S.J. Principles of cancer therapy: oncogene and non-oncogene addiction. ,2Nagel R.