Aimee Molineux

Manchester

Senior Editorial Account Manager at AZoNetwork

Senior Editor at AZoLifeSciences

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Articles

Scalable, Smart, and Accessible: The Future of Lab Automation

2 weeks ago | news-medical.net | Aimee Molineux

To begin, could you provide an overview of Trilobio and the motivation behind its founding? Thank you. I’m Roya, CEO and co-founder of Trilobio. Our mission is to make fully automated laboratories accessible to every biologist. We’ve been operating for about two and a half years, and our core innovation is a suite of modular robots—what we call Trilobots—designed to fully automate workflows in molecular and synthetic biology.
Air quality monitoring for harmful particulate

1 month ago | news-medical.net | Aimee Molineux

The World Health Organization (WHO) defines air pollution as “contamination of the indoor or outdoor environment by any chemical, physical or biological agent that modifies the natural characteristics of the atmosphere”.1 From an environmental perspective, polluted air can cause acid rain, crop damage, decrease plant growth and productivity, and cause harm to wildlife.
Element Six and Master Drilling Announce Strategic Partnership

1 month ago | azom.com | Aimee Molineux

Element Six (E6), a pioneer in the development and manufacturing of polycrystalline diamond (PCD) and ultra-hard materials, and Master Drilling, a global leader in drilling and mechanized rock excavation technology solutions, today announce a new global partnership.
The evolution of lipid nanoparticles

1 month ago | news-medical.net | Aimee Molineux

When developing new pharmaceuticals, many challenges are faceted. These include evading the immune system, the risk of cytotoxicity, and getting US Food and Drug Administration (FDA) approval. Image Credit: Genizer LLCOvercoming these challenges relies upon proven developmental and analytical methods, steps to reduce patient harm, and techniques to extend the blood circulation time.
Why choose high-pressure homogenization for cell disruption?

1 month ago | news-medical.net | Aimee Molineux

High-pressure homogenization has many advantages in cell disruption. This article summarizes some of the key benefits of this method. Image Credit: Genizer LLCPowerfulHigh-pressure homogenization is a powerful technique that can rapidly break apart stubborn cells, for example, by limiting the number of passes needed to disrupt them. ScalableAs a highly scalable method, high-pressure homogenization is suitable for use at the R&D scale in a laboratory setting, up to a manufacturing setup.
Choosing the right liposome extrusion option

1 month ago | news-medical.net | Aimee Molineux

Three key questions should be considered when selecting a liposome extrusion option. This article answers those questions in relation to Genizer’s range of tools. Image Credit: Genizer LLCWhat pore size is required? The choice of homogenizer will likely be dictated by the desired pore size. For example, a solo homogenizer can achieve a liposome size of 20–30 nm, but any tool with extrusion capabilities allows for a greater choice of pore size.
mRNA Vaccines and Liposome Nanoparticles

2 months ago | news-medical.net | Aimee Molineux

mRNA vaccines sprang to prominence because of their usage in COVID-19 vaccinations. Gloved hand-holding mRNA vaccine. Image Credit: Genizer LLCWhat is mRNA? Ribonucleic acid (RNA) is a genetic material that a ribosome reads while producing a protein. It provides instructions to the cell on how to construct a protein. What Does RNA Have to Do With Vaccines?
Anti-CD20 mAbs profiling

2 months ago | news-medical.net | Aimee Molineux

CD20, a transmembrane calcium channel required for B cell activation, proliferation, and differentiation, has emerged as a key therapeutic target for B-cell malignancies and autoimmune disorders. Its selective expression on B-cells—from the late pre-B cell stage to memory cells, but not on early pre-B cells or plasma cells—makes it an ideal target for monoclonal antibodies.
In vitro methods for TL1A screening

2 months ago | news-medical.net | Aimee Molineux

TL1A, commonly called TNFSF15, belongs to the tumor necrosis factor family. TL1A is expressed in a variety of immune cells, including monocytes, macrophages, dendritic cells, T cells, and others. It competitively binds to death receptor 3 (DR3) or decoy receptor 3 (DCR3), providing a stimulatory signal to downstream signaling pathways.
Structural characterization of lgC variants

2 months ago | news-medical.net | Aimee Molineux

Immunoglobulin G (IgG) is the dominant antibody isotype in human serum and appears in four variants: IgG1, IgG2, IgG3 and IgG4. Given their critical role in the immune system, IgGs are a major focus of research, particularly regarding their structure and functional properties. IgGs are beta-sheet-rich proteins composed of two identical heavy chains and two identical light chains linked by disulfide bonds.