AZoLifeSciences

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA study published in Advanced Science examined mechanical changes in fibronectin fibers during breast cancer progression. The researchers found that fibronectin fibers lose tension as tumors become invasive. This loss of tension may serve as a mechanical biomarker linked to tumor grade. Tumor grading is essential for diagnosis and treatment, as it helps predict aggressiveness, treatment response, and recurrence risk.

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study in Nature Communications examined how RNA polymerase I (Pol I) responds to abasic (Ap) site formation—the most common type of DNA damage. The researchers found that Pol I helps maintain genome integrity by stalling at these lesion sites. This stalling prevents the buildup of faulty transcripts, regulates ribosomal RNA (rRNA) production, and exposes the damaged DNA to repair proteins.

2 weeks ago | azolifesciences.com | Lexie Corner |Chinta Sidharthan

Reviewed by Lexie CornerInfectious disease control, vaccine durability, and immune-based therapies all rely on one key principle: immune memory. Understanding how the immune system remembers past encounters with pathogens—and how it responds to reinfections—is essential for developing better public health strategies. Image Credit: Motortion Films/Shutterstock.comWhat Triggers Long-Term Immune MemoryImmune memory is a defining feature of the adaptive immune system.

2 weeks ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA new study in Nature Communications explores how combinations of global change (GC) factors influence soil microbial communities. The results show that multiple GC treatments can affect soil microbes differently than individual factors alone. These findings support the importance of studying combined environmental stressors, which better reflect real-world conditions where multiple changes occur at once.

2 weeks ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study in Advanced Science presents a method for studying early human embryology by bioprinting epiblast-like structures from human-induced pluripotent stem cells (hiPSCs). The model forms a disc-shaped structure that resembles the epiblast layer in early human embryos. During gastrulation, the epiblast gives rise to the three germ layers—ectoderm, mesoderm, and endoderm—which later form organs and tissues.