AZoLifeSciences

Welcome to AZoLifeSciences, a freely accessible platform dedicated to the life science sector. Drawing from the extensive experience of News-Medical, a top global source for medical and life science news, AZoLifeSciences is committed to delivering the most recent insights in a clear and easy-to-navigate format.

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Looking to the Past: What Fossilized Tissues Can Teach Us About Modern Illness

4 days ago | azolifesciences.com | Lexie Corner |Vijay Kumar Malesu

Reviewed by Lexie CornerWhen you hear the word fossil, you probably think of bones or teeth—remnants of long-extinct creatures. But what if fossils could also tell us about disease? Researchers are now looking beyond hard tissues to study fossilized proteins—molecular fragments that can survive for millions of years. Through a growing field called paleoproteomics, scientists are uncovering how conditions like cancer may have evolved, and how ancient species coped with disease.
Three-Dimensionally Reconstructed Kidney Glomerulus Simulates Structural and Functional Characteristics In Vitro

6 days ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA study published in Advanced Healthcare Materials describes the bioengineering of three-dimensional (3D) kidney glomerular microtissues that replicate the glomerular filtration barrier (GFB) structure and mechanical environment. The model was developed to support studies of podocyte-related diseases by simulating biomechanical forces important to podocyte health.
Repairing DNA Double-Strand Breaks May Improve Genomic Stability by Limiting Organelle-to-Nucleus Gene Transfer

6 days ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study in Nature Plants examined the genetic regulation of endosymbiotic gene transfer (EGT) in plants. Researchers found that deoxyribonucleic acid (DNA) double-strand break repair (DSBR) pathways reduce gene transfer from cell organelles to the nuclear genome. In contrast, deficiencies in DSBR pathways—specifically in DNA ligase IV (LIG4) and DNA polymerase theta (POLQ) mutants—led to a marked increase in EGT frequency.
Study Identifies SMARCB1 and MEOX2 Genes as Growth Regulators of Lung Cancers

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study published in Cancer Gene Therapy examined the genetic contributions of mesenchyme homeobox 2 (MEOX2) and switch/sucrose non-fermentable-related matrix-associated actin-dependent regulator of chromatin subunit B1 (SMARCB1) in lung cancer. The results suggest that MEOX2 is associated with tumor growth promotion, while SMARCB1 appears to act as a tumor suppressor.
Meta-Analysis Identifies Genome-Level Associations of FOXP4 Gene With Long COVID

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study published in Nature Genetics reports a genome-wide association study (GWAS) aimed at identifying genetic factors linked to long-term effects of coronavirus disease 2019 (COVID-19), also known as post-acute sequelae of COVID-19 (PASC). The study found that variants of the forkhead box P4 (FOXP4) gene are associated with an increased risk of PASC.
Extracellular RNA Profiling Recommendations: Results From exRNAQC, a Comprehensive Assessment of Pre-Analytical Factors for Quality Control

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study in Nature Communications investigated how pre-analytical factors affect the transcriptome of blood-based extracellular RNA (exRNA, or cell-free RNA) biomarkers. The researchers established guidelines for blood collection tube type, RNA purification methods, and processing time to help optimize exRNA profiling. These recommendations aim to support both researchers planning exRNA studies and manufacturers evaluating new products.
How Is Estrogenic Activity Measured in the Environment?

1 week ago | azolifesciences.com | Lexie Corner |Stefano Tommasone Ph.D

Reviewed by Lexie CornerCertain compounds in the environment can mimic or interfere with the natural hormone estrogen, a property known as estrogenic activity. These interactions are often linked to endocrine-disrupting chemicals (EDCs), which can alter hormonal systems and lead to effects such as reproductive disorders, developmental issues, and increased cancer risk. Monitoring estrogenic activity provides a practical way to assess chemical contamination in water and sediment.
Autophagy: A Double-Edged Sword in Cancer and Protein Conformational Disorders

2 weeks ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent review in FEBS Letters explores the role of autophagy in cancer and protein conformational disorders. Autophagy helps maintain cellular homeostasis. In cancer, it can suppress tumor growth in early stages but promote tumor survival in advanced stages. In protein diseases, autophagy clears toxic protein aggregates from cells and tissues.
How Close Are We To Lab-Grown Organs?

2 weeks ago | azolifesciences.com | Priyom Bose |Lexie Corner

Reviewed by Lexie CornerLab-grown organs, commonly known as organoids or mini-organs, are small, self-organizing structures developed in the laboratory to mimic the structure and function of human organs.1 While not yet fully functional or transplantable, these structures allow researchers to study organ development, model disease, and explore potential treatments.
Addressing Protein Leakage in Cells to Improve the Accuracy of Single-Cell Proteomic Data

2 weeks ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study in Nature Communications highlights a key challenge in single-cell proteomics: protein leakage. Focusing on murine tracheal cells, the research team examined how leakage can skew protein quantification and, by extension, the biological insights derived from these studies. By identifying and removing permeabilized cells, those that have lost proteins due to membrane damage, from analysis, researchers can significantly improve data quality and reliability.