AZoLifeSciences

Welcome to AZoLifeSciences, a freely accessible platform dedicated to the life science sector. Drawing from the extensive experience of News-Medical, a top global source for medical and life science news, AZoLifeSciences is committed to delivering the most recent insights in a clear and easy-to-navigate format.

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Understanding the Role of Non-Coding RNAs in Neurodegeneration

2 days ago | azolifesciences.com | Priyom Bose |Lexie Corner

Reviewed by Lexie CornerNon-coding RNAs (ncRNAs) are RNA molecules that do not encode proteins but are involved in dynamic cellular regulatory processes.1 These molecules influence various central nervous system (CNS) functions, including neural development, brain aging, synaptic activity, and cognitive performance. A clearer understanding of their role in the pathogenesis of neurodegenerative disorders could support the development of novel diagnostic and therapeutic approaches.
How Are Gut Organoids Used to Model Human Digestive Function?

1 week ago | azolifesciences.com | Lexie Corner

Reviewed by Lexie CornerGut organoids are three-dimensional (3D), stem cell-derived structures that mimic the cellular composition and functions of the human gastrointestinal (GI) tract.
Restoring Alpha-Synuclein to Support Synaptic Function and Neurotransmission

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent Nature Communications study explored how synaptic vesicle (SV) composition changes with age and α-synuclein (αSyn)-related disease. The researchers focused on the role of αSyn in maintaining synaptic health, with the goal of informing therapies that could restore normal function by adjusting αSyn levels. This protein, known for accumulating in Lewy bodies, is a key driver of neurodegeneration in disorders such as Parkinson’s disease (PD).
Role of LADs and Epigenetic Pathways in Nuclear Architecture During Early Mouse Embryo Development

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study published in Cell investigates how lamina-associated domains (LADs) contribute to nuclear genome organization in early-stage mouse embryos. Focusing on the zygote and two-cell stages, the researchers examined the interplay between chromatin structure, nuclear architecture, and epigenetic pathways. Their findings show how the nuclear lamina influences genome positioning and stability during early development.
Memories of Cold Experiences Influence Metabolism and Thermoregulation

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study published in Nature reveals that recalling cold experiences can trigger significant physiological responses in the body, boosting metabolism, thermogenesis in brown adipose tissue (BAT), and the breakdown of glucose and lipids. This memory-induced thermoregulation suggests potential applications for treating metabolic conditions like diabetes and obesity.
3D Printing Collagen Scaffolds with Perfusable Systems for Tissue Engineering

1 week ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerA recent study published in Science Advances introduces a new approach to three-dimensional (3D) printing that integrates cells and extracellular matrix (ECM) into biologically functional scaffolds. Image Credit: luchschenF/Shutterstock.comThese collagen-based, high-resolution, internally perfusable scaffolds, referred to as CHIPS, work in tandem with a customizable vascular and perfusion organ-on-a-chip reactor system (VAPOR).
What Is Forensic Serology?

1 week ago | azolifesciences.com | Lexie Corner |Stefano Tommasone Ph.D

Reviewed by Lexie CornerForensic serology is the analysis of bodily fluids, such as blood, semen, and saliva, during legal and criminal investigations. It helps identify and evaluate biological evidence at crime scenes, often playing a key role before more advanced tests are run. Today, DNA profiling offers unmatched accuracy in linking biological material to individuals. So why does serology still matter?
Dr. Jeremy Poschmann’s data-driven approach to immune profiling and translational science

2 weeks ago | azolifesciences.com | Lexie Corner |Pooja Toshniwal Paharia

Reviewed by Lexie CornerIn a recent Genomics Psychiatry interview for the Innovators & Ideas series, Dr. Jeremy Poschmann of the French National Institute of Health and Medical Research (INSERM) and Nantes University discusses his data-focused approach to unraveling disease risk. By integrating multi-omics data and immune profiling, Dr. Poschmann explores how pre-existing immune conditions shape individual responses to pathogens.
New Drug Combo Shows Promise Against Aggressive Leukemia in Landmark Study

2 weeks ago | azolifesciences.com | Lily Ramsey |Pooja Toshniwal Paharia

Reviewed by Lily Ramsey, LLMThe researchers of a recent study published in Nature present a novel drug combination to treat acute myelogenous leukemia (AML). Drugs that inhibit lysine-specific demethylase 1 (LSD1) and glycogen Synthase Kinase 3 (GSK3) rewire transcriptional genes to promote myeloid cell differentiation while inhibiting cell (tumor) proliferation.
The Future of Chicken? Scientists Grow Whole Cuts in a Bioreactor

3 weeks ago | azolifesciences.com | Lily Ramsey |Pooja Toshniwal Paharia

Reviewed by Lily Ramsey, LLMIn a recent study published in Trends in Biotechnology, researchers developed a novel hollow fiber bioreactor (HFB) to generate chicken skeletal muscle tissues, exemplifying large-scale tissue engineering. The bioreactor enables centimeter-scale production of tissues with active perfusion through vessel-mimicking channels that facilitate myoblast differentiation.